This is a list of supervillains appearing in DC Comics who are or have been enemies of the superhero Superman. Several of Superman's opponents (most notably Darkseid and Brainiac) are or have been foes of the Justice League as well. Due to his long publication history and broad scope of activities, Superman's adversaries exist in every known capacity: humans, metahumans, androids, sorcerers, empowered animals, other aliens (such as Kryptonians), mythical/supernatural creatures, corrupt doppelgängers of himself (imposters, clones, or parallel universe counterparts), interdimensional beings (Mr. Mxyzpltk, Vyndktvx), and even deities.
Central rogues gallery In alphabetical order (with issue and date of first appearance):
Villain First appearance Description Anti-Monitor Crisis on Infinite Earths #2 (May 1985) The villain behind Crisis on Infinite Earths, an event that rebooted the DC Multiverse. The Anti-Monitor is one of the most powerful beings in the DC Multiverse. This character has a strong metafictional nature. Atomic Skull Superman #323 (September 1976) Albert Michaels was given radiation treatments that gave him atomic eye-blasts and worked his way up from an agent of SKULL to becoming its leader. The Adventures of Superman #483 (October 1991) Joseph Martin's superhuman powers manifested after exposure to the Dominators' gene-bomb; the film buff began to hallucinate that he was a 1930s movie hero called the Atomic Skull and that Superman was his nemesis. Bizarro Superboy #68 (October 1958) Bizarro was created when Superboy was exposed to a "duplicating ray" and was later destroyed in the same story. Action Comics #254 (July 1959) Lex Luthor exposed Kal-El, now Superman, to another duplicating ray, this time creating an adult Bizarro. This Bizarro later created a Bizarro Lois Lane and left with her into space. In accordance with the science fiction concepts of Superman stories of the era, Bizarro relocated to "the Bizarro World," a cubical planet called Htrae (Earth spelled backwards) which operated under "Bizarro logic" (e.g., it was a crime to do anything good or right) and which Bizarro populated with duplicates of himself and Bizarro Lois Lane, as well as Bizarro versions of Superman's supporting cast and the other DC heroes and villains. The Man of Steel #5 (December 1986) Bizarro was a flawed clone created by Lex Luthor's staff of scientists. Superman (vol. 2) #160 (September 2000) Post-Crisis, another Bizarro was created when the Joker conned Mr. Mxyzptlk out of 99% of his powers and created a Bizarro World. Bloodsport (Robert DuBois) Superman (vol. 2) #4 (April 1987) A gun-toting mercenary with Kryptonite bullets. Brainiac Action Comics #242 (July 1958) Brainiac is an alien cyborg or android from the planet Colu and one of the most dangerous villains in the DC Universe. He utilizes advanced weaponry (such as force fields and shrinking rays) and is capable of physically matching or overpowering Superman as well as creating and manipulating computer systems. Bruno Mannheim Superman's Pal Jimmy Olsen #139 (July 1971) Mannheim is one of Metropolis' most powerful gangsters and the leader of Intergang. Cyborg Superman The Adventures of Superman #466 (May 1990) Hank Henshaw is an astronaut who died as a result of a doomed mission on board the space shuttle Excalibur. Because Superman failed to save him, Hank Henshaw blames him for the loss of his original body, as well as the death of his wife. Reduced to a formless entity that inhabits mechanical bodies, the Cyborg desires to cause Superman equal pain. Henshaw masqueraded as a resurrected Superman after the hero's apparent death, claiming to be the result of Superman's remains being reconstructed into cybernetic form. Action Comics #252 (May 1959) Zor-El was introduced as the new Cyborg Superman following The New 52, a relaunch of the DC Universe. Zor-El was rescued from Krypton's destruction by Brainiac and was reconfigured as a cyborg to be his scout for looking for stronger species in the universe.Supergirl (vol. 6) #22 Darkseid Superman's Pal Jimmy Olsen #134 (December 1970) Uxas, son of Heggra, alien dictator of the planet Apokolips. As with gods in other mythologies, Darkseid is incredibly powerful, but cannot escape his ultimate destiny. It has been foretold that Darkseid will meet his final defeat at the hands of his son, Orion, in a cataclysmic battle.