Cardinal Sin, cardinal sin, or cardinal syn may refer to:

Sins Seven deadly sins, often called the "cardinal sins" Mortal sin (Catholicism) The three cardinal sins in Judaism, see Self-sacrifice in Jewish law

People Jaime Sin (1928–2005), Filipino cardinal and archbishop of Jaro (1972–1974) and Manila (1974–2003)

Music Cardinal Sin (band), a Swedish death/black metal band formed in 1995 "Cardinal Sin", a song by Black Sabbath from their 1994 album Cross Purposes "Cardinal Sin", a song by Conception from their 1997 album Flow "Cardinal Sin", a song by Powerwolf from their 2013 album Preachers of the Night "The Cardinal Sin", a song by Dead Can Dance from their 1985 album Spleen and Ideal

Other arts and entertainment Cardinal Syn, a 1998 3D fighting game for the PlayStation The Cardinal Sins, a novel by Andrew Greeley Cardinal Sin (Banksy), a sculpture by graffiti artist Banksy

See also Cardinal sine