James Gascoyne-Cecil or Gascoyne may refer to:
James Gascoyne-Cecil, 2nd Marquess of Salisbury (1791–1868), English Conservative politician James Gascoyne-Cecil, 4th Marquess of Salisbury (1861–1947), Chancellor of the Duchy of Lancaster James Victor Gascoyne (1892–1976), English World War I flying ace See also James Cecil (disambiguation)