The following highways are numbered 491:
Canada Manitoba Provincial Road 491
Cuba
San Cristobal–Bahia Honda Road (1–491) 2–491 (Cuba)
Israel Route 491 (Israel)
Japan Japan National Route 491
United States Interstate 491 (cancelled proposal) U.S. Route 491 Delaware Route 491 Florida State Road 491 (former) Maryland Route 491 Pennsylvania Route 491 Puerto Rico Highway 491