Barril is a Spanish surname. Notable people with the surname include:
Bernat Solé i Barril (born 1975), Spanish industrial engineer and politician from Catalonia Eduardo Barril (born 1941), Chilean actor and theatre director José Barril (born 1992), Spanish football player Pilar Barril (1931–2011), Spanish tennis player Joan Barril (1952–2014), Catalan journalist and writer Paul Barril (born 1946), former officer of the French Gendarmerie Nationale Rogelio Barril (1898–?), Spanish footballer