Man on a Mission may refer to:

"Man on a Mission", a song by Gamma Ray on the 1995 album Land of the Free "Man on a Mission", a song by Hall & Oates on the 2003 album Do It for Love "Man on a Mission", a song by Hemingway Corner "Man on a Mission", a song by John Kay and Steppenwolf on the 1987 album Rock & Roll Rebels "Man on a Mission", a song by Richard Ashcroft on the 2002 album Human Conditions "Man on a Mission", a song by Van Halen on the 1991 album For Unlawful Carnal Knowledge "man on a mission", a song by DDG, featuring Kyle Richh and NLE Choppa "Man on a Mission", a song by the Black Keys on their 2025 album No Rain, No Flowers Men on a Mission, a professional wrestling tag team