A knuckle is a joint on the hand.
Knuckle or knuckles may also refer to:
Arts, entertainment, and media Knuckle (film) a 2011 documentary about bare knuckle boxing in Ireland Knuckle Bine, a character from the anime/manga series Hunter × Hunter Knuckles the Echidna, a recurring character from the Sonic the Hedgehog video game series Knuckles the Echidna (comics), American comic book series Knuckles (TV series), television miniseries
Biology and anatomy Knuckles, the dorsal crenulations (bumps) of the gray whale where most whales have a dorsal fin Knuckle-walking, a form of quadrupedal walking in which the forelimbs hold the fingers in a partially flexed posture that allows body weight to press down on the ground through the knuckle Pork knuckle, a part of a pig's leg used as the basis of the traditional German dish Eisbein
People with the name Knuckles Boyle (1909-1943), American football player Frankie Knuckles (1955–2014), American DJ, record producer, and remixer Willis Knuckles (1946–2014), Liberia politician
Other Brass knuckles (also called knuckles), weapons used in hand-to-hand combat Knuckle coupler, a railway coupling, a mechanism for connecting rolling stock in a train Knuckle joint (mechanical), used to connect the two rods which are under the tensile load Knuckles Mountain Range, Sri Lanka
See also Knuckle Sandwich (disambiguation) Knuckleball, or knuckler, a baseball pitch