Charles Nichols may refer to:
Charles Archibald Nichols (1876–1920), politician from the U.S. state of Michigan Charles August Nichols (1910–1992), American animator and film director Kid Nichols, born Charles Augustus Nichols (1869–1953), Major League Baseball pitcher and Hall of Famer Charles D. Nichols, American pharmacologist and psychedelic researcher C. Walter Nichols, American chemist