Jan Hofmeyr may refer to:
Jan Christoffel Hofmeyr (1829–1898), South African notary, financier, benefactor and Mayor of Cape Town Jan Hendrik Hofmeyr (Onze Jan), (1845–1909), known as "Our Jan" (Onze Jan), journalist and South African politician, leader of the Afrikaner Bond political party of the Cape Colony Jan Hendrik Hofmeyr (1894–1948), nephew of "Our Jan", Rhodes Scholar, university professor and South African politician Jan-Hendrik S. Hofmeyr (born 1953), South African biologist and complexity theorist (1871–1937), Afrikaner lawyer and politician