Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).
There are four types, classified by the number of the position acted upon:
Carbon Hydroxysteroid Ketosteroid 3α-HSD 3α-Androstanediol Dihydrotestosterone 3α-HSD 3α-Etiocholanediol 5β-Dihydrotestosterone 3β-HSD Pregnenolone Progesterone 3β-HSD 17α-Hydroxypregnenolone 17α-Hydroxyprogesterone 3β-HSD Dehydroepiandrosterone Androstenedione 3β-HSD Androstenediol Testosterone 11β-HSD Cortisol Cortisone 17β-HSD Androstenedione Testosterone 17β-HSD Androstanedione Dihydrotestosterone 17β-HSD Estrone Estradiol 20β-HSD Progesterone 20α-Dihydroprogesterone
See also Steroidogenic enzyme Steroid hydroxylase
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