The Diocese of Santa Ana is a Latin Church ecclesiastical territory or diocese of the Catholic Church in El Salvador. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of San Salvador. The Diocese of Santa Ana was erected on 11 February 1913.

Bishops Ordinaries Giacomo Richardo Vilanova y Meléndez (1914–1953) Benjamin Barrera y Reyes, M.I. (1954–1981) Marco René Revelo Contreras (1981–1998) Romeo Tovar Astorga, O.F.M. (1999–2016) Miguel Angel Moran Aquino (2016– )

Auxiliary bishops Benjamin Barrera y Reyes, M.J. (1952–1954), appointed Bishop of Santa Ana Lorenzo Michele Joseph Graziano, O.F.M. (1961–1965), appointed Coadjutor Bishop of San Miguel Fernando Sáenz Lacalle, O.F.M. (1984–1995), appointed Archbishop of San Salvador Luis Morao Andreazza, O.F.M. (2003–2007), appointed Bishop of Chalatenango José Elías Rauda Gutiérrez, O.F.M. (2008–2009), appointed Bishop of San Vicente

Territorial losses Year Along with To form 1986 Diocese of Sonsonate

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