Kupka is a surname. Notable people with the surname include:
František Kupka (1871–1957), Czech painter and graphic artist Stephen Kupka (born c. 1946), American baritone saxophone player and composer Theofil Kupka (1885–1920), Silesian politician
See also 5363 Kupka, main-belt asteroid Kupka, Hlyboka Raion, a village in Ukraine