Fryxell is a surname. It is most commonly used in Sweden and America. Notable people with the surname include:
Anders Fryxell (1795–1881), Swedish historian Fritiof Fryxell (1900–1986), American geologist and mountaineer Greta Fryxell, (1926–2017), American marine scientist Paul Fryxell (1927–2011), American botanist Regina Fryxell (1899–1993), composer of Lutheran hymns Roald H. Fryxell (1934–1974), American geologist and archaeologist
See also Fryxell (crater), a lunar crater Lake Fryxell in Antarctica