DeMille or De Mille is a surname. Notable people with the surname include:

Agnes De Mille, American dance and choreographer Beatrice deMille, English-born American playwright and screenwriter Cecil B. DeMille, American film director Constance Adams DeMille, American actress Evelyn de Mille (1919–2013), Canadian bookseller Henry Churchill de Mille, American playwright James De Mille, Canadian writer Katherine DeMille, Canadian-born American actress Nelson DeMille, American author Oliver DeMille, American author and educator Richard de Mille, American journalist and author William C. deMille, American screenwriter and film director