Scipio Africanus was a Roman general who defeated Hannibal.

The name may also refer to:

Scipio Aemilianus (185-129 BC), also known as Scipio Africanus the Younger, adoptive grandson of the original Scipio Africanus Scipio Africanus (slave) (1702–1720), West African British slave Scipio Africanus (play), a 1718 historical tragedy by Charles Beckingham Scipio Africanus: The Defeat of Hannibal, a 1937 Italian propaganda film

See also Scipio Africanus Jones (1863–1943), African American educator, jurist, and politician Scipio Africanus Sam Mussabini (1867–1927), English athletics coach best known for his work with Harold Abrahams Italian cruiser Scipione Africano, an Italian warship of World War II