Plouffe is a French surname. People with the surname include:
Bridget Plouffe, American politician David Plouffe (born 1967), American campaign manager Katherine and Michelle Plouffe (born 1992), Canadian basketball players and twin sisters Maeve Plouffe (born 1999), Australian cyclist Simon Plouffe (born 1956), Canadian mathematician Simon Plouffe (filmmaker), Canadian documentary filmmaker Steve Plouffe (born 1975), Canadian retired ice hockey goaltender Trevor Plouffe (born 1986), American baseball player La Famille Plouffe, Quebec TV series of the 1950s (and revived in the 1980s) The Plouffe Family (film) (French: Les Plouffe), 1981 Canadian drama film
See also Bailey–Borwein–Plouffe formula, a formula for computing The Crime of Ovide Plouffe (French: Le Crime d'Ovide Plouffe), Canadian film and television miniseries from Quebec L'Abord-à-Plouffe, Quebec () in the southwest of the city of Laval Pouf