Epe or EPE may refer to:

Places Epe, North Rhine-Westphalia, Germany Epe, Netherlands Epe, Lagos, Nigeria Eastern Peripheral Expressway, National Capital Region, India

Science Electric potential energy Elvis Presley Enterprises, an American entertainment company England's Past for Everyone, an English historical research project Ephenidine European Parliament of Enterprises, a business organization Everyday Practical Electronics, a British hobbyist magazine Expanded polyethylene Extrasolar Planets Encyclopaedia, an online database of exoplanets End-Permian Extinction, a mass extinction at the end of the Paleozoic

See also Épée, a weapon used in sport fencing Treaty of Epe