The Diocese of Zacatecoluca () is a Latin Church ecclesiastical territory or diocese of the Catholic Church in El Salvador. It is a suffragan diocese in the ecclesiastical province of the metropolitan Archdiocese of San Salvador. The Diocese of Zacatecoluca was erected on 5 May 1987.
Ordinaries Romeo Tovar Astorga, O.F.M. (5 May 1987 – 17 December 1996), appointed Coadjutor Bishop of San Miguel Elías Samuel Bolaños Avelar, S.D.B. (27 February 1998 – 6 July 2026) Ramiro Ernesto Landaverde Orellana (since 6 July 2026)
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