"Brother and Sister" is a fairy tale known, in different variants, throughout Europe.

Brother and Sister or Sister and Brother, or variation, may also refer to:

Siblings, known as brother and sister Brother and Sister (Greek fairy tale), a Greek fairy tale Brother and Sister (sculpture), an 1890 bronze by Auguste Rodin Little Brother And Little Sister, another title for Hansel and Gretel Brother and Sister, a poem by Lewis Carroll

Film and TV Brother and Sister (1976 film), a Japanese film Brother and Sister (2010 film), an Argentine film Brother and Sister (2022 film), a French film

Music Brother and Sister (opera), an opera by composer Henry Bishop and librettist William Reeve, 1815 Brother, Sister, an album by indie rock band mewithoutYou, 2006 Brother Sister, an album by the Brand New Heavies 1994 Brother/Sister, an album by the band Hymns 2006

See also Brothers and Sisters (disambiguation) Sister & Brother, a 1999 album by Melky Sedeck Sisters & Brothers, a 2011 film