Neoptolemus may refer to the following people:
People Neoptolemus, son of Achilles and Deidamia in Greek mythology Neoptolemus (general) (died 321), general of Alexander the Great Neoptolemus I of Epirus, king of Epirus, son of Alcetas I, father of Alexander I of Epirus and Olympias, grandfather of Alexander the Great Neoptolemus II of Epirus, king of Epirus, nephew of Alexander the Great Neoptolemus (Pontic army officer), general of King Mithradates Eupator