The Diocese of Tuxtepec () is a Latin Church ecclesiastical territory or diocese of the Catholic Church in Mexico. It is a suffragan in the ecclesiastical province of the metropolitan Archdiocese of Antequera. The diocese's episcopal see is San Juan Bautista Tuxtepec.
Ordinaries Bishops of Tuxtepec (Roman Rite) José de Jesús Castillo Rentería, M.N.M. (1979 – 2005), retired José Antonio Fernández Hurtado (2005 – 2014), appointed Archbishop of Durango José Alberto González Juárez (2015 – 2026), appointed Bishop of Campeche Apostolic administrator Guadalupe Antonio Ruíz Urquín (2026 – Present), Prelate of Huautla
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