O'Toole is an Irish surname. It may refer to:
People O'Toole family, a leading family in Gaelic Leinster O'Toole (surname), including a list of persons and characters with the name
Other uses O'Tooles GAC football and hurling club in Dublin Ensign O'Toole, a military sitcom starring Dean Jones, which aired on NBC, 1962-1963 Slugger O'Toole, Irish weblog St. Laurence O'Toole Pipe Band , the name of more than one United States Navy ship
See also Other anglicizations of ó Tuathail: Tohill Toal (disambiguation)