Cowanesque may refer to:
Cowanesque, Pennsylvania, a community in Tioga County Cowanesque Lake, a US Army Corps of Engineers flood prevention lake in Pennsylvania Cowanesque River, a tributary of the Tioga River in Pennsylvania and New York Cowanesque Rock, an island of Alaska Cowanesque Valley Railroad Corning, Cowanesque and Antrim Railway USS Cowanesque (AO-79), originally named the SS Fort Duquesne, a type T2 tanker