Ayatollah Mohammad Reza Tavassoli (; 1931 – 16 February 2008) was an influential Iranian theologian, reformist politician, a close associate of Ayatollah Ruhollah Khomeini, and was the first chief of staff of the Office of the Supreme Leader of Iran from 1979 to 1989. Tavassoli was a member of the Expediency Discernment Council of the Islamic Republic of Iran. He belonged to the Militant Clerics League. Ayatollah Tavassoli simultaneously held a seat in the 3rd Assembly of Experts.

Tavassoli died on 16 February 2008, from a heart attack, while delivering a speech to the Expediency Council. He was 77 years old at the time of his death.Iranian Ayatollah dies during speech, Agence France-Presse (February 17, 2008).

See also List of members of Constitutional Amendment Council of Iran List of ayatollahs

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