Tsentralnyi District () may refer to the following places in Ukraine:
Tsentralnyi District, Dnipro, an urban district of Dnipro Tsentralnyi District, Kherson, an urban district of Kherson Tsentralnyi District, Mariupol, an urban district of Mariupol Tsentralnyi District, Mykolaiv, an urban district of Mykolaiv Tsentralnyi District, Simferopol, an urban district of Simferopol