Route 220 or Highway 220 may refer to:
Australia Sunraysia Highway
Canada Manitoba Provincial Road 220 Newfoundland and Labrador Route 220 Quebec Route 220 Saskatchewan Highway 220
China China National Highway 220 (G220)
Costa Rica National Route 220
Japan Japan National Route 220
United Kingdom A220 road B220 road
United States Interstate 220 U.S. Route 220 Arkansas Highway 220 California State Route 220 Georgia State Route 220 Iowa Highway 220 Kentucky Route 220 Maine State Route 220 Route 220 (Connecticut–Massachusetts) Minnesota State Highway 220 New Mexico State Road 220 New York State Route 220 Ohio State Route 220 Tennessee State Route 220 Texas State Highway 220 Utah State Route 220 (former) Washington State Route 220 (former) Wyoming Highway 220