OTB may refer to:

Arts On the Boards, an arts organization in Seattle, Washington Out of the Blue (American band), a jazz ensemble

Computing One True Brace, a software coding convention for formatting loops, functions, if statements, and blocks Orfeo toolbox, an open source library for remote sensing image processing OTA Bitmap, an image file specification for mobile phones (*.otb files)

Sports and games Off-track betting, sanctioned gambling on horse racing outside a race track Over-the-board, in chess, played on a single physical chessboard (as opposed to correspondence or online chess) Off the ball, in association football, a player's movement when not in possession of the ball

Companies OTB Group, a holding company for several fashion brands Office du Thé du Burundi, a public company that supports the tea industry in Burundi OTB Sports, a media company in Ireland

Other Occupied Territories Bill, proposed Irish law to ban trade with Israeli settlements Off the boat, a pejorative slang phrase for newly arrived immigrants Overberg Test Range, or Overberg Toetsbaan, a missile test range in South Africa Overseas Trust Bank, a defunct bank of Hong Kong The Old Timer's Bulletin, an amateur radio history journal