William Ayres may refer to:
William Ayres (cricketer) (1906–1978), South African cricketer William Augustus Ayres (1867–1952), Democratic member of the U.S. House of Representatives from Kansas William Hanes Ayres (1916–2000), Republican member of the U.S. House of Representatives from Ohio William Orville Ayres (1817–1887), American physician and ichthyologist Bill Ayers (born 1944), American professor and former radical