C27 or C-27 may refer to:
Vehicles Aeritalia C-27A Spartan, an Italian military transport aircraft Alenia C-27J Spartan, an Italian military transport aircraft Bellanca C-27 Airbus, a military transport aircraft used by the United States Army Air Corps Caspar C 27, a German seaplane trainer Caudron C.27, a French biplane , a C-class submarine of the Royal Navy
Other uses C27 road (Namibia) Bill C-27 (39th Canadian Parliament, 2nd Session) Caldwell 27, an emission nebula Caterpillar C27, a diesel engine