Giovanni Antonio de' Rossi (1616–1695) was an Italian architect of the Baroque period, active mainly in Rome.

Life He was a contemporary of Carlo Rainaldi. In 1657, he completed the sacristy of Tivoli Cathedral.Le meraviglie di Roma: Dal Rinascimento ai giorni nostri Vittorio Sgarbi - 2011 "Giovanni Antonio De Rossi Sue opere fuori Roma: Santa Maria della Cima a Genzano (iniziata dal Peparelli nel 1636) e la sacrestia del duomo di Tivoli (1657)." That same year, he designed the renovations to Chiesa di San Rocco all'Augusteo, adding a dome, the sacristy and a new chapel."Church of San Rocco all'Augusteo", Turismo Roma, Major Events, Sport, Tourism and Fashion Department He created the shrine over the high altar, designed by Rainaldi, in Santa Maria in Campitelli to house the icon of Santa Maria in Portico."Church of Santa Maria in Portico in Campitelli", Turismo Roma

At about the time he became the architect of the Monte di Pietà in Rome until his death and built its oval chapel from the 1650s onwards.

For Pope Clement X he carried out an extensive and hurried refurbishment (1670–76) of the family's Palazzo Altieri near the Church of Il Gesù .

He erected the church of Santa Maria in Campo Marzio in 1682-1685 and was involved in the design of the Cappella Lancellotti in St John Lateran.

His Palazzo D'Aste-Bonaparte on Piazza Venezia influenced the later designs of Alessandro Specchi's Palazzo de Carolis and Tommaso de Marchis' Palazzo Millini-Cagiati.

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