Second skin may refer to:
Film and television Second Skin (1999 film), a Spanish romantic drama film Second Skin (2008 film), an American documentary film "Second Skin" (Deep Space Nine), a 1994 TV episode
Literature Second Skin (novel), a 1964 novel by John Hawkes Second Skin (Decide Your Destiny), a 2008 adventure book based on Doctor Who
Music Second Skin (band), an American gothic rock band
Albums Second Skin (John Course and mrTimothy album), 2008 Second Skin (The Mayfield Four album), 2001
Songs "Second Skin" (song), by the Gits, 1991 "Second Skin", by the Chameleons from Script of the Bridge, 1982 "Second Skin", by Hugo Largo from Drum, 1998 "2econd Skin", by Moonspell from Sin/Pecado, 1998