Substance may refer to: Matter, anything that has mass and takes up space
Chemistry Substance (chemistry), a material with a definite chemical composition Drug, a chemical agent affecting an organism
Arts, entertainment, and media Music Substance, a 2002 album by Blank & Jones Substance (Joy Division album), 1988 Substance 1987, a New Order album "Substance", a song by Haste the Day on the album Burning Bridges "Substance" (song), a 2022 song by Demi Lovato "Substance", a 2000 dance track by Blu Peter
Other media The Substance, 2024 film SubStance, an interdisciplinary journal on literature published by the University of Wisconsin Press Metal Gear Solid 2: Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty
Religion and philosophy Dravya, a term used in Jainism to refer a substance Ousia, term for substance in ancient Greek philosophy and Christian theology Substance theory, an ontological theory positing that a substance is distinct from its properties
Software Substance 3D Modeler, software from Adobe for 3D content creation
See also Substance use (disambiguation) Substance control (disambiguation) Substantial (rapper)