Schaffner (German for "conductor") is a surname that is mainly found in German and English-speaking regions. Notable people with the surname include:

Barbara Schaffner (born 1968), Swiss politician Daniel Schäffner (born 1981), German politician Dwite H. Schaffner (1889–1955), American Medal of Honor recipient Franklin J. Schaffner (1920–1989), American film director Hans Schaffner (1908–2004), Swiss liberal politician Jake Schaffner (born 2004), American baseball player Jakob Schaffner (1875–1944), Swiss novelist John Henry Schaffner (1866–1939), American botanist Kenneth F. Schaffner (born 1939), American philosopher Nicholas Schaffner (1953–1991), American writer on popular music William Schaffner (1941–1970), United States Air Force pilot

See also Schaffer American clothiers Hart Schaffner & Marx, now known as Hartmarx