Mother's Little Helpers or Mother's Little Helper may refer to:
Nickname for the drug Diazepam (Valium) Cougars, Inc., developed under the title Mother's Little Helpers, a 2010 indie film "Mother's Little Helper", a 1966 Rolling Stones song "Mother's Little Helper" (Medium), a 2007 Medium episode "Mother's Little Helper" (Once Upon a Time), a 2017 episode of Once Upon a Time "Mother's Little Helper", a Casualty episode "Mother's Little Helpers" (Helstrom), a 2020 Helstrom episode
See also "Brother's Little Helper", an episode of The Simpsons television series Santa's Little Helper, a fictional dog from The Simpsons