Petrosino is a town in Sicily, Italy.

Petrosino may also refer to:

Lieutenant Joseph Petrosino Park, Bensonhurst, Brooklyn, New York City Petrosino Square, a park in lower Manhattan in New York City, named for Joseph Petrosino

People with the surname Joseph Petrosino (1860–1909), New York City police officer and organized crime investigator Kiki Petrosino (born 1979), American poet and professor Natty Hollmann (aka Natty Petrosino; 1936–2021), Argentinian philanthropist, humanitarian, actor, and model

See also Maria Perosino (1961–2014), Italian author and art historian Petrosina, a suborder of marine haplosclerid sponges