NBC 21 may refer to one of the following television stations in the United States:
KNBN in Rapid City, South Dakota KNPG-LD in St. Joseph, Missouri KQTV/KVFD-TV in Fort Dodge, Iowa (formerly with NBC from 1953 to 1977; now defunct) KTVZ in Bend, Oregon WFMJ-TV in Youngstown, Ohio WPTA-DT2, a digital channel of WPTA in Fort Wayne, Indiana