S19 may refer to:

Aircraft Letov Š-19, a Czechoslovak airliner Rans S-19 Venterra, an American light sport aircraft Short S.19 Singapore III, a British flying boat SIAI S.19, an Italian racing flying boat Sikorsky S-19, an experimental Russian biplane

Rail and transit S19 (Rhine-Ruhr S-Bahn), an S-Bahn line in Germany S19 (ZVV), a line of the Zürich S-Bahn in Switzerland Line S19 (Milan suburban railway service), Italy Aioiyama Station, in Midori-ku, Nagoya, Aichi, Japan Mizue Station, in Edogawa, Tokyo, Japan Niki Station, in Yoichi District, Hokkaido, Japan Tsuruhashi Station, in Osaka, Japan

Roads S19 Xinnong–Jinshanwei Expressway, China Expressway S19 (Poland) County Route S19 (California), United States

Other uses 40S ribosomal protein S19 , a submarine of the Royal Navy SREC (file format), an ASCII encoding format for binary data developed by Motorola , a submarine of the United States Navy British NVC community S19, a swamps and tall-herb fen community in the British National Vegetation Classification system