Despot may refer to:
Despot (court title), a Byzantine court title Despotism, a form of government in which power is concentrated in the hands of one individual Despot (rapper), rapper Alec Reinstein's stage name , a TV series Despot (vehicle), armoured multifunctional vehicle
People with the given name Despot Badžović (1850–1930), teacher, activist of the Serbian national movement
People with the surname Despot (surname) Blaženka Despot (1930–2001), Croatian philosopher and sociologist Branko Despot (1942–), Croatian philosopher Dragan Despot (1956–), Croatian actor Iacob Heraclid Despot (1527–1563), Prince of Moldavia Ilija Despot (1885–1970), Croatian poet and writer Veljko Despot (born 1948), Croatian record producer