James Chambers may refer to:
Arts, entertainment and publishing James Chambers, English musician with Bob Kerr's Whoopee Band James Chambers (writer) (born 1970), American author and comic book writer James S. Chambers (publisher) (1821–1904), American publisher of the Philadelphia Bulletin James S. Chambers (editor) (1853–1923), American editor of Public Ledger and grandfather of Whittaker Chambers James F. Chambers Jr., (1913–2006), American newspaperman Jimmy Cliff (1944–2025), Jamaican reggae musician (born James Chambers)
Sport Jimmy Chambers (footballer) (Robert James Chambers, 1908-1977), Northern Irish footballer, see List of Bury F.C. players (25–99 appearances) James Chambers (English footballer) (born 1980), mostly played for English clubs James Chambers (Irish footballer) (born 1987), mostly played for Irish clubs, and Ireland
Other fields James Chambers (mayor) (1864–1934), American politician James Chambers (pastoralist) (1811–1862), South Australian colonist James Chambers (politician) (1863–1917), Irish lawyer and Unionist James Cox Chambers (born 1950s), American billionaire heir James Cox Chambers Jr., son of the above, known as Fergie Chambers
Other meanings USS James S. Chambers, schooner in the American Civil War
See also Jimmy Chambers (singer) (born 1946), vocalist with Londonbeat