Sant'Onofrio is Italian for "St. Onuphrius". This name may refer to:
Places Sant'Onofrio, Calabria, a municipality in Vibo Valentia, Calabria, Italy Sant'Onofrio, Campli, a frazione (submunicipal division) in Teramo, Abruzzo, Italy Sant'Onofrio, Lanciano, a frazione in Chieti, Abruzzo, Italy
Religious buildings Sant'Onofrio, Rome, a church in Rome, Lazio, Italy Hermitage of Sant'Onofrio, Serramonacesca, Abruzzo, Italy Hermitage of Sant'Onofrio al Morrone, Sulmona, Abruzzo, Italy
Other Sant'Onofrio a Porta Capuana, a music conservatory in Naples, Campania, Italy
Artworks Sant'Onofrio Altarpiece by Luca Signorelli, on display at the Duomo of Orvieto, Umbria, Italy