Deep Six may refer to:
Books and comics Deep Six (comics), a set-index article listing several uses, including: Deep Six (Marvel Comics), two different Marvel Comics teams Deep Six (DC Comics), a 1971 DC Comics supervillain team Deep Six (G.I. Joe), a fictional character in the G.I. Joe universe Deep Six (novel), a 1984 Dirk Pitt novel by Clive Cussler The Deep Six (novel), a 1953 novel by Martin Dibner; basis for the 1958 film (see below) Deepsix, a 2000 science fiction novel by Jack McDevitt
Film and television The Deep Six, a 1958 World War II war film directed by Rudolph Maté Deep Six (Teen Titans), a television episode DeepStar Six, a 1989 American horror/scifi film based in an underwater military research facility
Music The Deep Six (band), a 1960s American pop/rock band Deep Six (album), a compilation of Seattle alternative rock bands, 1986 "Deep Six" (song), by Marilyn Manson, 2014 "Deep Six", a song by Big Black from Racer-X, 1994 "Deep Six", a song by Matthew Good Band from Underdogs, 1997
Other uses Deep Six (Alberta politics), a group of Progressive Conservative members of the Legislative Assembly of Alberta, elected in the 1993 provincial election Deep Six, a move used by the professional wrestler Baron Corbin