Route 122 or Highway 122 may refer to:
Brazil BR-122
Canada New Brunswick Route 122 Ontario Highway 122 (former) Prince Edward Island Route 122 Quebec Route 122
Costa Rica National Route 122
Cuba Punta de Carta Road (1–112) Road to Bolondron (3–122)
India National Highway 122 (India) State Highway 122 (Rajasthan)
Japan Japan National Route 122
Nigeria A122 highway (Nigeria)
United Kingdom B122 road.
United States U.S. Route 122 (former) Alabama State Route 122 County Route 122 (Lee County, Alabama) Arkansas Highway 122 California State Route 122 (never built) Connecticut Route 122 Florida State Road 122 County Road 122 (Baker County, Florida) Georgia State Route 122 Hawaii Route 122 Illinois Route 122 Indiana State Road 122 (former) Iowa Highway 122 K-122 (Kansas highway) (former) Kentucky Route 122 Louisiana Highway 122 Maine State Route 122 Maryland Route 122 Massachusetts Route 122 Massachusetts Route 122A M-122 (Michigan highway) (former) Minnesota State Highway 122 (former) County Road 122 (Hennepin County, Minnesota) Missouri Route 122 New Hampshire Route 122 New Jersey Route 122 New Mexico State Road 122 New York State Route 122 County Route 122 (Erie County, New York) County Route 122 (Fulton County, New York) County Route 122 (Jefferson County, New York) County Route 122 (Montgomery County, New York) County Route 122 (Niagara County, New York) County Route 122 (Onondaga County, New York) County Route 122 (Rensselaer County, New York) County Route 122 (Steuben County, New York) County Route 122 (Tompkins County, New York) North Carolina Highway 122 Ohio State Route 122 Rhode Island Route 122 South Carolina Highway 122 Tennessee State Route 122 Texas State Highway 122 (former) Texas State Highway Spur 122 Farm to Market Road 122 Utah State Route 122 Vermont Route 122 Virginia State Route 122 Virginia State Route 122 (1923-1925) (former) Virginia State Route 122 (1925-1928) (former) Virginia State Route 122 (1928-1933) (former) Washington State Route 122 West Virginia Route 122 Wisconsin Highway 122
Territories Puerto Rico Highway 122