Sean or Seán MacManus may refer to:
Seán MacManus (politician) (born 1950), Irish Sinn Féin politician in Sligo Sean McManus (television executive) (born 1955), American television network executive Seán McManus (priest), County Fermanagh-born, US-based nationalist activist priest
See also Shaun McManus (born 1976), Australian rules footballer Shawn McManus (born 1958), American comic book artist