MPX may refer to:
Technology MPX filter, a function found in cassette decks Multiplexing, the process of combining multiple analog or digital signals into one Multiplexer, an electronic device which accomplishes this task
Computing Multi-Pointer X, an extension to X.Org MPX Microsoft Project Exchange File Format, a Microsoft Project file format Intel MPX, a set of Memory Protection Extensions to the x86 instruction set architecture .mpx, a video file format in the Kingston K-PEX 100 IBM 1800 MPX, in the list of operating systems MPX bus, a PowerPC CPU bus, for example in the PowerPC G4
Other uses MPX Energia, former name of the Brazilian utility company Eneva MPI MPXpress, a train locomotive SIG MPX, a submachine gun from SIG Sauer An abbreviation for mpox, an infectious viral disease Motion Picture Exchange, acronym for a global sales exchange company that serves as a liaison to distributors Misima language, an Austronesian language in Papua New Guinea by ISO 639-3 code