Spy vs. Spy is a wordless black and white comic strip published in Mad magazine since 1961.

Spy vs. Spy may also refer to:

Spy vs. Spy (1984 video game), the first computer game based on the comic strip Spy vs Spy (1999 video game), a game released on Game Boy Color by Kotobuki System Co., Ltd. Spy vs. Spy (2005 video game) Spy vs Spy (album), the 1989 recording of Ornette Coleman compositions by American multi-instrumentalist, John Zorn Spy vs. Spy (band), Australian rock band English songwriter Billy Bragg in his 1983 Life's a Riot with Spy vs Spy.