High Sierra may refer to:
Places High Sierra (biome), a region of California Sierra Nevada (U.S.), a mountain range in California also called the High Sierra or High Sierras High Sierra Trail, which crosses the Sierra Nevada
Arts, entertainment, and media High Sierra (film), 1941 High Sierra Music Festival, held in Quincy, California since 1991 John Muir's High Sierra, an Oscar-nominated short documentary
Computing and technology High Sierra Format, a CD-ROM filesystem developed in 1986 macOS High Sierra, an operating system for Apple computers
Other uses High Sierra, an American outdoor brand owned by luggage manufacturer Samsonite International
See also Sierra mountains (disambiguation)