Kgositsile is a surname. Notable people with the surname include:
Baleka Mbete-Kgositsile (born 1949), South African politician Keorapetse Kgositsile (1938–2018), South African poet and political activist Melba Johnson Kgositsile (1940–1994), American civil rights activist Thebe Neruda Kgositsile (born 1994), American rapper and record producer