High Lonesome may refer to:
Books High Lonesome: New & Selected Stories, 1966–2006, a short story collection by Joyce Carol Oates High Lonesome, a 1962 Western novel by Louis L'Amour High Lonesome, a 1996 short story collection by Barry Hannah
Films High Lonesome (film), a 1950 Western film directed by Alan Le May A Father for Charlie, also released as High Lonesome, a 1995 television film directed by Jeff Bleckner
Places Coeur d'Alene Mountains, part of the Bitterroot Mountain Range in the Rocky Mountains of North America
Music High lonesome, a genre of bluegrass music pioneered by Bill Monroe The High Lonesome, an alternative country band whose lead singer was Larry Poindexter High Lonesome, an indie rock band named after the short story collection by Barry Hannah
Albums High Lonesome (Randy Travis album), a 1991 album by Randy Travis High Lonesome (Charlie Daniels album), a 1976 album by Charlie Daniels Band High Lonesome (Country Gentlemen album) High Lonesome, a 1999 album by Longview
Songs "High Lonesome", a song by Avail from their 2000 album One Wrench "High Lonesome", a song by The Gaslight Anthem from their 2008 album The '59 Sound "High Lonesome", a song by Jesse Malin from his 2003 album The Fine Art of Self Destruction "High Lonesome", a song by Caspian from their 2012 album Waking Season