Van Cleef is a Dutch surname. Notable people with the surname include:
Jan Van Cleef (1646–1716), Flemish painter Joos van Cleve (also spelled Jos van Cleef) (1485–1540), painter from Cleves Cornelius van Cleve (1520–1567), painter and son of Joos Lee Van Cleef (1925–1989), American film actor who primarily starred in westerns June Van Cleef (born 1941), American photographer Nathan van Cleef, one of the villains of Shanghai Noon (modeled after Lee Van Cleef)
See also Van Cleef & Arpels, French jewelry house