The 2006 Louisville Cardinals football team represented the University of Louisville in the 2006 NCAA Division I FBS football season. The team, led by Bobby Petrino in his fourth year at the school, played their home games in Papa John's Cardinal Stadium. Playing in their second year in the Big East Conference, the team finished the regular season with eleven wins and one loss and were conference champions. They represented the Big East in the 2007 Orange Bowl and with the win ended the season with a 12–1 record. The team ended the season ranked sixth in the nation.

Preseason The Cardinals finished the 2005 season with a 9–3 record, including a loss in the Gator Bowl. After the loss, they were ranked 19th in the nation. Returning eight starters from their 2005 offense, including Brian Brohm and Michael Bush and nine starters on a defense that allowed 320 yards a game the team was picked, by the Big East media, to finish second in the conference.

Coaching changes After assistant coach Tony Levine left the Cardinals for a job in the NFL, he was replaced as special teams coordinator and outside linebackers coach by Tom McMahon. McMahon had eight years of assistant coaching experience at Utah State. Also added to the staff as a new assistant strength coach was Bryan Dermody.

Roster changes Although returning 17 starters from 2005, the team lost other key players to the 2006 NFL draft. Four players were taken in the draft, three of which were defensive starters. From the offense, offensive guard Jason Spitz was taken in the third round by Green Bay. From the defense, end Elvis Dumervil was taken by Denver, linebacker Brandon Johnson by Arizona and tackle Montavious Stanley by Dallas.

Recruiting The Cardinals signed 25 recruits for the new class. Included in the top-40 class were three four-star recruits on offense, a five-star recruit on defense, and another four four-star recruits on defense.

Preseason honors Five Cardinals' players were honored as part of pre-season watchlists for national awards.

Brian Brohm – Maxwell Award, Walter Camp Award, and Davey O'Brien Award Michael Bush – Maxwell Award and Walter Camp Award Art Carmody – Lou Groza Award Nate Harris – Dick Butkus Award Eric Wood – Outland Trophy and Rimington Trophy

Schedule

Game summaries Kentucky

The Cardinals opened their season against in-state rivals the Kentucky Wildcats, playing for the Governor's Cup. Kentucky, led by fourth year coach Rich Brooks and quarterback Andre' Woodson, came into the game not having beaten the Cardinals in four years. Louisville took an early lead with three Michael Bush touchdown runs in the first half, added to a touchdown pass by Brian Brohm and a field goal by Art Carmody. Woodson threw a pair of touchdown passes at the end of the half to bring the teams into halftime with the Cardinals leading 31–14. On their first possession of the second half, Michael Bush, already having 124 yards rushing, was injured. It was eventually revealed that he had broken his leg and would be out for the rest of the season. Despite the loss of Bush, the Cardinals still managed to score four more touchdowns in the game, including two by his replacement, George Stripling. With another long touchdown pass by Woodson and a kickoff return for a touchdown by Keenan Burton, the game ended with the Cardinals winning 59–28. With the win, the Cardinals moved up a spot to 12th in the nation.

Temple

The Cardinals next went on the road to face the Temple Owls led by second-year head coach Al Golden and quarterback Adam Dimichele. The Cardinals scored early and often with 5 rushing touchdowns in the first half added to a 57-yard passing touchdown by Brohm to give them a 42–0 lead at halftime. The second half wasn't better for the Owls, still failing to score and giving up two more rushing touchdowns and a pair of field goals by Art Carmody. When the game was over the Cardinals won 62–0 and had amassed 671 total yards of offense. After the game, Louisville kept their number 12 ranking.

Miami (FL)

The Cardinals first big test of the year came against the 15th ranked Miami Hurricanes, led by sixth year head coach Larry Coker and quarterback Kyle Wright. Louisville had never beaten the Hurricanes before in 10 previous meetings. Prior to the game, Hurricane players came to midfield to stomp on the Cardinals logo, causing a small altercation. Early, Louisville's strong offense struggled against the powerful Miami defense, a defense that had only given up 200 yards a game. Miami scored first on a rushing touchdown, but would be unable to score again. The Cardinals, led by Brohm, scored on a field goal and a long touchdown pass to take a 10–7 lead at halftime. In the third quarter, Brohm injured his thumb and would be taken out of the game. It was later reported that he would be out for four to six weeks. His loss didn't stop the Cardinals offense though, with running back Kolby Smith scoring two rushing touchdowns in the third quarter, and Brohm's replacement, Hunter Cantwell, throwing another touchdown in the fourth to bring the final score to 31–7 in favor of the Cardinals. Although they had been averaging over 600 yards per game, the Cardinals were held to 382, but it was enough to defeat the Hurricanes. After the game the Cardinals moved to 9th in the nation, while the Hurricanes dropped out of the polls for the first time since 1999.

Kansas State

The Cardinals next faced the Kansas State Wildcats on the road. The Wildcats, led by first-year head coach Ron Prince and quarterback duo Josh Freeman and Dylan Meier, were 3–0. They had the number 14th ranked defense in total yards in the nation and had not given up an offensive touchdown since their first game. However, the Cardinals first possession, a 97-yard drive that ended with Cantwell throwing a 19-yard touchdown pass, ended the streak. Though the Cardinals struggled moving the ball for the rest of the half, even turning the ball over a few times, they were able to score on a field goal by Art Carmody to take a 10–0 lead to the half. In the second half, Louisville was able to score on a pair of runs to take a 24–0 lead, but Kansas State finally got on the board with a 69-yard run by Thomas Clayton. After a failed two-point conversion attempt, neither team could score again and Louisville won 24–6. Their offense, ranked first in the nation in total yards with 563 per game, was once again held for under 400 yards. With the win, the Cardinals moved to eighth in the rankings.

Middle Tennessee

The Cardinals next went on the road to face the Middle Tennessee Blue Raiders, led by first-year head coach Rick Stockstill and quarterback Clint Marks. The Cardinals scored on an early field goal, but the Blue Raiders took the lead when Damon Nickson returned the ensuing kickoff 88 yards for a touchdown. After a field goal by the Blue Raiders gave them a 10–3 lead, the Cardinals opened up the scoring with two more field goals and a pair of touchdown passes by Hunter Cantwell to Mario Urrutia. At halftime the Cardinals led 23–10. In the second half, Cantwell threw another touchdown and Kolby Smith and Anthony Allen both ran for touchdowns for the Cardinals. Clint Marks threw a touchdown in the fourth quarter, but it was too late for the comeback, giving the Cardinals a 44–17 win. With the win, the Cardinals moved up to seventh in the rankings.

Cincinnati

The Cardinals next started their Big East schedule playing the Cincinnati Bearcats in a homecoming game. The Bearcats, led by third-year head coach Mark Dantonio and quarterback Dustin Grutza, though struggling with a 3–3 record on the season, had played number 1 ranked Ohio State and highly ranked Virginia Tech, and had held early leads on both. Cardinal quarterback, Brian Brohm returned from his thumb injury, but struggled in the first half. The Bearcats took an early lead on a field goal and after the Cardinals tied the game, took another lead with a touchdown pass by Grutza. The Cardinals were able to score twice at the end of the half, including on a 1-yard pass by Brohm, to take a 13–10 lead to halftime. After the half, the Cardinals scored on an Anthony Allen rush and another field goal by Art Carmody to have a 23–10 lead in the fourth quarter. Grutza threw another touchdown pass with four minutes left in the game and had a chance win with another pass in the endzone, however it was knocked down by Cardinal cornerback Gavin Smart to preserve the win. The Cardinals won 23–17 and continued their 15-game home winning streak. With the win, the Cardinals moved to sixth in the nation.

Syracuse

The Cardinals next went to Syracuse to face the Orange. The Orange, led by second-year head coach Greg Robinson and quarterback Perry Patterson, were looking for their first conference win in two years. Though both teams struggled to move the ball in the first quarter, the Orange took the first lead with two field goals in the second quarter. However, just before the half, the Cardinals took the ball on an 80-yard drive that culminated in a 2-yard touchdown by Anthony Allen. With the score, the Cardinals took a 7–6 lead to the half. In the third quarter the only score allowed was on a 5-yard run by Kolby Smith for the Cardinals. Later in the fourth quarter, Allen scored his second touchdown to give the Cardinals a 21–6 lead. Patterson was finally able to connect with Mike Williams for a 37-yard touchdown to bring the Orange to within 8. The Orange looked ready to attempt to tie the game when the Cardinals bobbled the ensuing kickoff and were pinned at their own 7, however, the Cardinals went on a 93-yard drive which was capped with another Smith touchdown run. With no time remaining, the Cardinals won 28–13. With the win the Cardinals moved to fifth in the nation.

West Virginia

The Cardinals next had their biggest game of the season playing the third ranked West Virginia Mountaineers, led by sixth-year head coach Rich Rodriguez and quarterback Pat White. The game was hyped to be the Big East game of the year, after the epic 2005 game, and seemed that the winner would have national title hopes with both ranked in the top-5 in the country and both tied with Rutgers for the lead in the Big East. The Cardinals took an early lead with an Art Carmody field goal, but gave up a 42-yard touchdown run to Steve Slaton later in the quarter to give the Mountaineers a 7–3 lead at the end of the quarter. On their next drive, Carmody kicked another field goal for the Cardinals, and when their defense stopped the Mountaineers, the Cardinals took a lead on the next drive on an Anthony Allen touchdown. After a long kickoff return, Pat White ran for his own touchdown to give the Mountaineers the lead once again, however, Carmody kicked a third field goal before the half to give the Cardinals a 16–14 lead at halftime.